She made her debut in Interview with the Vampire, the film based on the Anne Rice novel of the same name. Her most famous performance to date was in Spider-Man
She has starred in other movies, like The Virgin Suicides, All I Wanna Do, Drop Dead Gorgeous, Dick, Bring it On, Get Over It, Crazy/Beautiful, and Mona Lisa Smile.
She won the 2002 Best Actress Silver Omb� at the Mar de Plata Film Festival for her performance as Marion Davies in Peter Bogdanovich's The Cat's Meow.